For most visitors, this is the ferry home: the end of a Sifnos stay of long lunches, pottery villages and walks between chapels, and the start of the journey back to Athens and the airport. It is also the easiest way to move from the western Cyclades to the mainland if you are carrying on elsewhere in Greece.
Two kinds of boat make the trip. Seajets high-speed craft cover it in around two and a half hours from spring to late autumn, while the conventional ships of Fast Ferries run all year and take roughly twice as long, with Aegean Sea Lines adding sailings in the cooler months. The slower ships are cheaper, carry cars and have more room to walk around.
Your choice often comes down to what you are doing after you land. Piraeus is Athens' main port, about 15 km south of the city centre and some 45 km from the airport, so an arrival in the early afternoon leaves time to get to a flight or a hotel, while a late conventional arrival is best followed by a night in Athens. Leave a generous buffer before any flight, because a delay at sea is common on windy days.
Book early for July, August and the end of Greek holidays, when boats back to Athens fill with returning visitors. Outside summer, not every day has a sailing, so plan your last night on Sifnos around the ferry rather than the other way round.